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The Journal of Advances in Parasitology

Research Article
J. Adv. Parasitol. 4(1): 1-8
Http://dx.doi.org/10.14737/journal.jap/2017/4.1.1.8
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Ahmad Mouhamad Mandour, Mahmoud Elhady Mouhamad Mounib, Hanan ElDeek Mouhamad Eldeek, Alzahraa Abdel Raouf Ahmad, Abdel Rahman Mahmoud Mouhamad Abdel Kader 

1Parasitology Department, Faculty of Medicine, Assiut University, Egypt; 2Obstetrics and Gynecology Department, Faculty of Medicine, Assiut University, Egypt.
 
Abstract | Toxoplasma gondii is an intracellular protozoan that can infect all mammals including man. It causes congenital infections in humans. Knowledge of its prevalence in pregnant women would be a valuable approach for planning appropriate preventive strategies. Meanwhile early diagnosis of toxoplasmosis in pregnant women is necessary to get effective treatment and prevent fetal complications. The current cross–sectional study aimed to determine the rate of T. gondii infection and maternal-fetal transmission in high risk pregnant women with complicated pregnancy outcomes in Assiut Governorate, Egypt. Out of 182 pregnant women who were screened for Toxoplasma-specific IgG and IgM antibodies with ELISA, 125 samples (68.7%) were seropositive. Seventy-three samples were IgG seropositive (IgG+/IgM−), showing that 40.1% of subjects were immune to Toxoplasma infection. Fifty-seven samples were seronegative (IgG-/ IgM-) meaning that 31.3% of subjects were susceptible to primary infection. The rate of probable acute Toxoplasma infection was 28.6% in all participants. (IgG+/IgM+ & IgG-/IgM+ were 13.2% & 15.4% respectively). Significant relations were found between Toxoplasma-specific IgG and residency in rural areas, consumption of milk/milk products, contact with soil, and eating undercooked meat or viscera. In conclusion, we reported high prevalence of T. gondii infection among pregnant women with adverse pregnancy outcomes associated with trans-placental transmission of infection in Assiut governorate, Egypt. Sources of infection revealed herein might represent potential threats for primary infection in seronegative women.

Keywords | Toxoplasma gondii, Pregnancy, Women, Prevalence, Egypt