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The Journal of Advances in Parasitology

Review Article
J. Adv. Parasitol. 5(4): 49-55
Http://dx.doi.org/10.17582/journal.jap/2018/5.4.49.55
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Adil M. Allahverdiyev*, Umut Ogluoglu, Melahat Bagirova, Emrah Sefik Abamor

Yildiz Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, Esenler, Istanbul,Turkey.

Abstract | Despite the struggle against leishmaniasis for many years, the effective treatment method of the disease is not possible and the number of the disease is increasing every year. This is due to the fact that parasites and vectors have developed resistance against medicines and insecticides .Moreover, an efficient vaccine has not been developed yet against leishmaniasis. The importance of exosomes, which are extracellular vesicles secreted by Leishmania parasites, is increasing day by day, as is the case with other infections. Exosomes are being extensively investigated for use in the diagnosis and treatment of some diseases. The number of studies in the literature related to the effect of exosomes on Leishmaniasis is very few. Accordingly, for the first time in this review, important information and suggestions have been given about the importance of exosomes secreted by Leishmania parasites in the struggle against Leishmaniasis and the future treatment plans on this subject. In this paper, we review that how exosomes, which are secreted from Leishmania, effect in the development of the disease, in parasitic virulence, in the triggering of host immune system and in the survival of parasites in the macrophage.

Keywords | Leishmania, Exosomes, Vesicles, Macrophage