Advances in Animal and Veterinary Sciences

Review Article
Adv. Anim. Vet. Sci. 6(1): 44-54
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Asinamai Athliamai Bitrus1,2*, Zakaria Zunita1, Mohammed Dauda Goni3, Innocent Thlama Mshelia4

1Research Unit, Microbial food safety and Antimicrobial resistance, Department of Veterinary Public health, Faculty of Veterinary Sciences, Chulalongkorn University, 10330 Pathumwan, Bangkok, Thailand; 2Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Malaysia; 3Unit of Biostatistics and Research Methodology,School of Medical Sciences, Health Campus,Universiti Sains Malaysia,16150 Kubang Kerian, Kelantan, Malaysia; 4Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B 1069 Maiduguri, Borno State, Nigera.

Abstract | The successful in vivo horizontal transfer of mobile genetic elements carrying resistance and virulence determinants have contributed immensely to a global dissemination of virulent and multi-drug resistant pathogens. The pathogenesis of MRSA infection is enhanced via initial colonization of the skin through the component of the microbial surface antigen recognizing adhesive matrix molecules and by their ability to evade host immune response. Furthermore, it was also observed that the genetic diversity of pathogenic MRSA is due to its’ ability to rapidly acquire resistance and virulence determinants. A characteristic feature that made it one of the most important nosocomial pathogen worldwide. Similarly, the expression of virulence gene in MRSA has been observed to be regulated by the accessory gene regulator system (agr). These system is made up of a series of genes whose product build up quorum-sensing regulatory mechanisms that is growth dependent. At a certain growth stage, the agr systems triggers a pronounced changes in the expression of genes called the quorum sensing. The findings of this review affirmed the importance of horizontal gene transfer in the dissemination of resistance and virulence determinants and as well as the genetic diversity of MRSA.

Keywords | Accessory gene regulators, Colonization, Horizontal gene transfer, Resistance, Virulence