Phone : 0092 300 7786573

Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 5(7): 299-306
View Full HTML
Download PDF

Sreenivasulu Dasari*, Muni Swamy Ganjayi, Balaji Meriga, Thyagaraju Kedam

Department of Biochemistry, Sri Venkatewara University, Tirupati, Andhra Pradesh, India.

Abstract | Acrylamide is a well proven neurotoxin and is a major environmental and food contaminant. Generally, birds are highly mobile in all environments and their developing embryo are the first victim of polluted environment caused by industrialization and agriculture system at various stages. However, data is lacking on birds species related to antioxidant defence system. The present study was aimed to analyze the potentiality of developing chick embryo’s brain glutathione S-tranferases (GSTs) to detoxify the toxic chemical agents such as acrylamide (AC). Findings of this study indicate that the high level expression of brain GSTs may detoxify the toxic chemical agents and therefore protect the brain. Excessive accumulation of toxic chemical agents such as AC can finally make injury to brain. Taken together, results of the study showed that as minimum as 6 parts per million of AC can cause cerebellar layers degeneration and vacuolation within 24 hours and 48 hours. Thus a minute quantity of AC is a potent neurotoxin for developing chicken embryos and efforts should be made to prevent such exposures for sufficient productivity of the poultry.

Keywords | Chick embryo, Brain GSTs, Acrylamide, Neurotoxicity, Brain injury