Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 4 (8): 405 - 410
View Full HTML
Download PDF

Rekha Khandia1, Pratibha Vishwakarma1, Abhinav Dwivedi1, Reena Mehra1, Anshumala Kujur1, Kuldeep Dhama2, Ashok Munjal1*

1Department of Genetics, Barkatullah University, Bhopal-462 026 (M.P.), India; 2Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122 (Uttar Pradesh), India.

Abstract | Angiogenesis is a vital physiological process of formation and development of new blood vessels (neovascularization) from pre-existing ones, essential for embryonic development and growth especially in the growing stages. Copper (Cu) is known to promote angiogenic factors like VEGF (Vascular Endothelial Growth Factor), FGF (Fibroblast growth factor), angiopoitin and others, and as per previous reports, depending upon the material, Cu sometimes inhibit angiogenesis. We investigated the effects of different Cu salts (Copper chloride, copper acetate, alkaline copper tartrate and copper carbonate) on the process of angiogenesis among chicken chorioallantoic membrane (CAM) model by assessing histopathological alterations. Out of the four Cu salts studied, copper carbonate was found to be pro-angiogenic and did not reveal any detrimental effect, and therefore can have potential to be explored as a therapeutic material under health conditions requiring neovascularization. Rest other Cu salts (Copper chloride, copper acetate and alkaline copper tartrate) investigated were anti-angiogenic and induced inflammation in experimental material. Observing the importance of Cu in neovascularization, its salts can be used in therapeutic strategy either for treating disorders caused by excess angiogenesis or reduced angiogenesis.

Keywords | Angiogenesis, Neovascularization, Endothelial cells, Chorioallantoic membrane, Copper salts, Therapy