Advances in Animal and Veterinary Sciences

Review Article
Adv. Anim. Vet. Sci. 3 (8): 422 - 429
http://dx.doi.org/10.14737/journal.aavs/2015/3.8.422.429
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Dhanavelu Muthuchelvan1*, Kaushal Kishor Rajak1, Muthannan Andavar Ramakrishnan1, Dheeraj Choudhary1, Sakshi Bhadouriya1, Paramasivam Saravanan2, Awadh Bihari Pandey1, Raj Kumar Singh3

1Division of Virology, Indian Veterinary Research Institute, Mukteswar Campus, Nainital, Uttarakhand 263 138, India; 2Indian Veterinary Research Institute, Hebbal Bengaluru, 560024, Karnataka, India; 3Indian Veterinary Research Institute, Izatnagar, 243122, India.

*Correspondence | Dhanavelu Muthuchelvan, Indian Veterinary Research Institute, Nainital, Uttarakhand, India; Email: drchelva@gmail.com

Abstract
Peste-des-petits-ruminants (PPR) is an acute or subacute, highly contagious viral disease of small ruminants, characterized by fever, oculonasal discharges, stomatitis, diarrhoea and pneumonia with high morbidity and mortality. Peste-des-petits-ruminants virus (PPRV), the etiological agent of PPR, is antigenically related to another rinderpest virus (RP) which was globally eradicated. PPR is gaining worldwide attention through the concerted effort of scientists working together under the aegis of global PPR research alliance (GPRA). The first homologous live attenuated vaccine was developed using Nigeria 75/1, which has been used worldwide. In India, live attenuated vaccines have been developed using Sungri 96, Arasur 87 and Coimbatore 97 viruses. In this review, the status of PPR and control strategy with special reference to the Indian context is comprehensively discussed.

Keywords | PPR, PPRV, Vaccine, DIVA, Eradication, Symptoms, Epidemiology, Diagnosis, Vaccines, Immunity, Control programme, Replication