Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 3 (1S): 10 -15. Special Issue-1 (Biotechnological and molecular approaches for diagnosis, prevention and control of infectious diseases of animals)
http://dx.doi.org/10.14737/journal.aavs/2015/3.1s.10.15
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Swati Dahiya1*, Neha Bhardwaj2, Sanjeev Bhardwaj2, Jyotsana Mehta2, Arun Sehgal, Minakshi Prasad3

1Department of Veterinary Microbiology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar- 125004, Haryana; 2Central Scientific Instrumentation Organisation (CSIO), Sector-30C, Chandigarh-160030; 3Department of Animal Biotechnology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-
125004, Haryana, India.

*Correspondence | Swati Dahiya, Lala lajpat Rai University of Vetrinary and Animal Sciences, Hisar, Haryana, India; Email: swatidahiya@yahoo.co.in

Abstract
Biofilm growth on catheter surface is a challenge for various biomedical applications. Microbial colonization on catheter’s surface leads to many infections. Silicone polymer is a routine material for catheter fabrication. In the present work, silver nanoparticles (NPs) and photosensitive non-toxic dye toluidiune blue (TB) embedded silicon polymer is synthesised by swell encapsulation method and characterised by UV spectroscopy. The embedded polymer showed high bactericidal activity against gram-positive bacteria Staphylococcus aureus (S. aureus) and gram-negative Proteus mirabilis (P. mirabilis) with least leaching effects which suggests their usage as a new weapon to fight catheter related infections.

Keywords | Catheter, Photosensitizer dye, Toluidine blue, Silver nanoparticles, Bactericidal