Advances in Animal and Veterinary Sciences

Review Article
Adv. Anim. Vet. Sci. 3 (2S): 25 - 31. Special Issue-2 (Reviews on Trends and Advances in Safeguarding Terrestrial /Aquatic Animal Health and Production)
View Full HTML
Download PDF

Shalini Sharma1*, Naveen Kumar2

1Department of Veterinary Physiology and Biochemistry, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India; 2Virology Laboratory, Division of Animal Health, Central Institute for Research on Goats, Indian Council of Agricultural Research, Makhdoom, P.O.-Farah, Mathura, UP-281122, India.

*Correspondence | Shalini Sharma, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India; Email:

Prior immunity can result in complete protection against a homologous agent. In the real world, however, each individual experiences multiple infections. Immune memory responses that are generated in an individual as a consequence of an initial or primary infection has been convincingly shown to influence the immune response and the course of infection of subsequent, unrelated pathogen challenge, by a process known as heterologous immunity. The fact that the host’s history of previous infections cannot be altered warrants our current understanding of the cellular mediators involved and the roles they play in regulating heterologous immunity. Several cellular mediators such as CD4, CD8T cells and various innate immune cells participate in mediating heterologous immunity. Regulatory T cells are an important subset of CD4T cells and here in this review we attempt to discuss our current understanding on the role of regulatory T cells (Tregs) in heterologous immune responses.

Keywords | Regulatory T cells, Heterologous infection