Budi Purwo Widiarso1*, Dias Aprita Dewi1, Kurniati Sarwendah2, Dhestalia Eka Pratiwi3

Abstract | Haemonchosis is a parasitic disease that often occurs in goats in Indonesia. In sub-tropical and tropical areas, the mortality, decreased production, stunted growth, and low weight gain due to haemonchosis have substantial economic impacts. Jackfruit (Artocarpus heterophyllus) is recognized as a plant that has the potential for anthelmintic activity because its leaves contain tannins. The aim of this study was to determine the in vitro effects of a crude aqueous extract of jackfruit leaves on the parasitic worm Haemonchus contortus. Six groups of 10 adult worms were immersed in different doses (0%, 0.25%, 0.5%, 0.75%, and 1%) of a jackfruit leaf extract or in albendazole (positive control) and assessed five times or as five replications every hour for up to 4 hours. Two-way ANOVA was used to analyze worm mortality rates at the various treatment doses and observation times, while one way ANOVA was used to analyze the differences in worm morphometry. The jackfruit extract at various doses and observation times had a significant effect on worm mortality and altered the worm morphometry, especially the male and female body length, cervical papilla width, spicula length in males, and vulva flap length in females. A 1% dose of jackfruit leaf extract caused the greatest worm mortality. The in vitro worm mortality and morphometry examinations support the use of Artocarpus heterophyllus aqueous crude leaf extracts as potential anthelmintics against Haemonchus contortus.

Keywords | Artocarpus heterophyllus, Haemonchus contortus,Goat, anthelmintic, in vitro