Atef A. Hassan*, Mareim H. Yousif, Hanaa M. M. Abd-Elkhaliq, Ahlam K. A. Wahba, Ahmed M.a. El-Hamaky

Abstract | The antimicrobial potential of selenium nanoparticle (SeNPs) singly or in combination with cinnamon oil were evaluated against causes of diarrhea in buffaloes. The pathogens of E. coli and C. albicans were recovered from animal feeds, drinking water and feces of diarrheic animals at the top of all other iso-lates. The green synthesized selenium nanoparticles and cinnamon oil were had significant antimicrobial potential than traditional antibiotics against E. coli and C. albicans. The inhibitory concentrations of Se-NPs against C. albicans and E. coli were (0.4 and 0.3 mg/ml) and for Cinnamon oil were (0.5 %), respec-tively. The combination of SeNPs and Cinnamon oil completely inhibited the growth of C. albicans and E. coli sp. at (0.2 mg Se NPs / 0.2 % Cinnamon oil). It is concluded that the synergistic activity of metals NPs Se NPs / cinnamon oil were urgently required to overcome the microbial resistance against the traditional antibiotics and decrease the concentrations used of nanoparticles to avoid its toxicity for animals.

Keywords | Selenium nanoparticles, Synergy, Nano-emulsion, Cinnamon oil, Antimicrobial, Nanotechnology