Zainab J. Malik1, Ali I. Al-ameedi2*, Zahraa M Ayad3, Maymunah Abdullah1

Abstract | Objective: The main objective of this work was to measure the impact of synthetic and natural propolis on infected wounds contaminated with pathogenic staphylococcus. aureus. Material and methods: Sixteen healthy local rabbits were classified into two similar group. All rabbits were anaesthetized by 2% lidocaine hydrochloride S/c as local anesthetic, then surgical incision was performed 3*4cm in the skin. From one day of wound infected with staph. Aureus, first 8 rabbits treated with 5% natural propolis while the animals from (9-16) treated with synthetic propolis, Results: Temperature, respiratory rate and heart rate were included in clinical criteria investigation. there were no significant (p ≤0.05) differences between groups. Macroscopic finding showed that the scar present greater quantity in the animals exposed to synthetic propolis than that in group one furthermore the histopathological findings exhibited that the wound healing in the treated group by natural propolis was quicker and better and the epithelial cells with more maturity so the skin back up near normal, while the synthetic propolis group showed early epithelization with mild regeneration of adnexa. Conclusions: The healing properties of propolis very encouraging to make more trials in different species and types of tissues furthermore to analysis of constituent of propolis by accurate methods.

Keywords | Propolis, Wound, Skin, Rabbit, Staphylococcus. Aureus