Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 1 (2S): 15 - 23. Special Issue-2 (Clinical Veterinary Practice-T rends)
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Siddharth Khattri1, Prakash Kinjavdekar*2, Amarpal2, Hari Prasad Aithal2, Abhijit Motiram Pawde2, Rohit Kumar3, Jasmeet Singh4
1 Private Veterinary Practitioner, Dehradun (Uttrakhand); 2Division of Surgery, Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly (Uttar Pradesh), India; 3Division of Surgery, Indian Veterinary Research Institute, Izatnagar-243 122, Bareilly (Uttar Pradesh), India; 4Department of Surgery and Radiology, Veterinary College, OUAT, Bhubaneshwar (Odisha)
*Corresponding author:

Sixteen clinical cases of urolithiasis in male buffalo calves of 4–6 months of age and 40–55 kg of weight were used in groups A and B. Group A animals were premedicated with dexmedetomidine (2.5 μg/kg body wt, IV), while in group B dexmedetomidine (2.5 μg/kg body wt, IV) and butorphanol (0.05 mg/kg body wt, IV) were used for premedication. Anaesthesia was induced by 1 % propofol in group A (2.50 ± 0.37 mg/kg) and B (1.99±0.29 mg/kg), and maintained by 1 % propofol with continuous intravenous infusion. A lower dose of propofol for induction and maintenance was required in group B than in group A, whereas recovery time, sternal recumbency time, standing time and duration of anaesthesia were similar in both groups. In both groups, HR and RR decreased significantly (P<0.01)up to 75 min. There was a gradual increase in RR after induction of anaesthesia in both groups, and a significantly higher RR was recorded from 45 to 75 min in group A. Rectal temperature decreased significantly in both groups up to 90 min. Haemoglobin, PCV and TLC decreased in both groups. Significant neutrophilia was recorded in group B and lymphocytopenia in both groups. Urea nitrogen, creatinine and glucose increased in both groups. MAP decreased significantly (P<0.05) after premedication up to the end of observation period in both groups. Decrease in SpO2 after premedication was recorded in both groups. All the animal of both groups recovered without any complications. It was concluded that dexmedetomidine–propofol combination can be used safely for total intravenous anaesthesia in uraemic buffalo calves, however, addition of butorphanol has a dose sparing effect on propofol induction and maintenance anaesthesia in uraemic buffalo calves.

Key Words: Buffalo calves, Butorphanol, Dexmedetomidine, Propofol