Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 8(s1): 18-25
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Ibrahim A. Ibrahim1, Abeir A. Shalaby1, Hoda ML. Abdallah2, Nermin F. El Zohairy2, Hoda I. Bahr1*

1Department of Biochemistry, Faculty of Vet. Medicine, Suez Canal University Ismailia 41522, Egypt; 2Department of Biochemistry, Animal Health Research Institute, Zagazig, Egypt.

Abstract | We determined the cardioprotective impact of ethanolic flaxseed seeds extract through an assessment of its immunomodulatory and antiangiogenic characteristics in rats fed with an atherogenic diet. Group 1 fed on the standard diet. Groups 2 and 3 fed on an atherogenic diet (AD) for 12 weeks. Groups 3 and 4 daily supplemented with ethanolic extract of flaxseed seeds (EEFS) 400mg/kg b.w starting from 7th week till the end of 12th week. AD-fed rats had increased serum lipids, CRI-I, CRI-II, cardiac enzymes, and pro-inflammatory markers. Compared to the AD-fed group, EEFS supplementation influenced hypo-lipidemic, anti-inflammatory, anti-angiogenic, and anti-atherogenic characteristics after AD- feeding. EEFS displayed antioxidant capacity in vitro and in vivo. Chromatographic analysis of EEFS demonstrated the presence of phenolic, flavonoid compounds, and vitamin C. The data concludes a safe application of EEFS in atherogenesis-induced cardiac disease management.

Keywords | Hyperlipidemia, Cardiac markers, Immunity, Linum usitatissimum