Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 8(8): 788-793
Http://dx.doi.org/10.17582/journal.aavs/2020/8.8.788.793
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Pawi Bawitlung Lalthanpuii, Kholhring Lalchhandama*

Department of Life Sciences, Pachhunga University College, Aizawl 796001, Mizoram, India.

Abstract | Praziquantel/pyrantel pamoate (PZQ/PTP) combination and albendazole (ABZ) are two commercially available anthelmintic drugs most commonly used for the treatment of different helminth infections. Their anthelmintic activity was studied in vitro against the poultry nematode, Ascaridia galli. Although both the drugs were effective, ABZ showed most prominent activity. Scanning electron microscopy of the nematodes revealed structural damaged induced by the drugs. Shrinkage of the cuticle, collapse of the lips, and formation of cuticular folds were the defining anthelmintic effects. Comparison based the drug efficacy and anthelmintic effects indicates that ABZ can be the drug of choice for helminthiasis due to nematodes.

Keywords | Anthelmintic drug, Cuticle, Helminthiasis, Nematode, Scanning electron microscopy