Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 8(7): 777-781
Http://dx.doi.org/10.17582/journal.aavs/2020/8.7.777.781
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Haritha GS*, Satish Kumar K., Amruth Kumar VVV

College of Veterinary Science, Rajendranagar, Hyderabad, Telangana 500030, India.

Abstract | The present study was undertaken to evaluate the efficacy of angiotensin converting enzyme inhibitor (Enalapril) and angiotensin II receptor antagonist (Losartas) along with a diuretic and supplemental therapy in dogs with idiopathic dilated cardiomyopathy. A total of 30 dogs with dilated cardiomyopathy were randomly allotted to treatment groups i.e., group I and II (15 dogs in each group). The echocardiographic left ventricle dimensions of the dilated cardiomyopathy affected dogs of group I and II showed significantly (P<0.01) increased LVEDd and LVEDs when compared with the mean values of healthy dogs. The other dimensions viz., LVPWd, LVPWs, IVSd and IVSs noted on day 0 among the different group of affected dogs were significantly low (P<0.05). There was significant increase in EPSS value (<0.01). With respect to Ejection Fraction and Fractional Shortening, the values on day 0 were significantly low (P<0.01). Group I was treated with Enalapril and group II with Losartan along with common diuretic torsemide in both the groups. All the dogs in group I showed recovery where as two dogs died in group II during the treatment period. The present findings reveal that dogs suffering with dilated cardiomyopathy can be treated with a combination of traditional ACEi like enalapril, superior diuretic like torsemide and supplemental neutraceuticle like L-carnitine, for earlier clinical recovery with no adverse drug reactions.

Keywords | Canine, Dilated cardiomyopathy, Enalapril, Losartan, Torsemide