Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 8(5): 524-530
Http://dx.doi.org/10.17582/journal.aavs/2020/8.5.524.530
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Stepan Yurievich Veselovsky1 ,Valery Alexandrovich Agoltsov1, Davud Abdulsemedovich Devrishov 2, Olga Mikhailovna Popova1, Nataliya Victorovna Solotova1*

1Department of Veterinary Medicine, Saratov State Agrarian University named after N.I. Vavilov, Russia, 410012, Saratov, Teatralnaya square, 1; 2Moscow Academy of Veterinary Medicine and Biotechnology named after K.I. Scriabin “; Russia, 109472, Moscow, Academician Scriabin Street, 23.

Abstract | The split-conjugated vaccine against brucellosis of animals was tested as a provocateur in order to identify sick (latent) animals in both brucellosis safe and brucellosis poor farms. After administration of the test vaccine, antibodies remained in the blood of healthy animals for up to 2.5 months, then disappeared, and antibodies remained in the blood of sick animals after 3.5, 4.5 and 7.5 months and gradually disappearing over time. The split-conjugated animal brucellosis vaccine has a “provocative effect”, exacerbates the infectious process and thereby makes it possible to identify sick animals. We recommend the use of a split-conjugated animal brucellosis vaccine in brucellosis-poor households in order to detect latent animals and create humoral immunity in animals while maintaining antibodies in the blood of animals for 2.5 months. In the case of small detection of animals with brucellosis in the farm (from 1 to 5 animals), we recommend using the vaccine to detect animals with brucellosis and to create immunity in healthy animals twice with an interval of 3 months. If a large number of animals with brucellosis in the farm (from 6 to 20 and above goals) are detected, we recommend using the vaccine once after eliminating the sick livestock, followed by the use of the vaccine from the Brucella abortus 82 strain, which must be vaccinated after passing calving (May - July). The split-conjugated animal brucellosis vaccine can be used on both non-pregnant and pregnant cows, as it does not cause abortion.

Keywords | Animal brucellosis, Split-conjugated vaccine, Latent brucellosis, Exacerbation of the brucellosis infection process.