Advances in Animal and Veterinary Sciences

Review Article
Adv. Anim. Vet. Sci. 7(s2): 107-116
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Ahmed M. Ammar1, Norhan K. Abd El-Aziz1, Marwa I. Abd El Hamid1*, Noha A. Gomaa2, Sama S. Mohamed2

1Microbiology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Sharkia, Egypt, 44511; 2Directorate of Veterinary Medicine, Zagazig, Sharkia, Egypt.

Abstract | Klebsiella spp. are Gram negative opportunistic pathogens, which cause many diverse community acquired and nosocomial infections. The infections caused by multidrug-resistant (MDR) bacteria are difficult to treat. In addition, Klebsiella spp. have several virulence factors, which play their role in pathogenesis and infectivity involving capsule, lipopolysaccharide, fimbrial and non-fimbrial adhesins, siderophores and its ability to form biofilms. Klebsiella biofilm is formed on biotic and abiotic surfaces like medical devices. It can protect the bacteria from antibiotics and host immune system leading to chronic infections and mortalities. Therefore, it is necessary to investigate new antibiofilm methods better than the conventional methods to eradicate the biofilm and thereby control Klebsiella infections. In this review, we will discuss Klebsiella virulence and its antibiotic resistance to give more insights into its capability for biofilm production and the application of the antibiofilm approaches for controlling its infection.

Keywords | Klebsiella, Virulence factors, Antibiotic resistance, Biofilm, Antibiofilm methods