Advances in Animal and Veterinary Sciences

Review Article
Adv. Vet. Sci. 7(s2): 71-78.
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Sawsan Mohamed Ali El-Sheikh1, Abd El-Alim Fouad Abd El-Alim1, Azza Ahmed Abd El-Ghaffar Galal1*, Rehab Gamal El-Sayed2, Naif Ahmed Al-Gabri3

1Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt; 2Faculty of Pharmacy, Zagazig University, Zagazig 44511, Egypt; 3Veterinary Department, Faculty of Agriculture and Veterinary Medicine, Thamar University, Dhamar 2153, Yemen.

Abstract | Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease that affects all the body systems in human and animals. Animal models have proven to be indispensable for the unraveling of pathophysiological mechanisms of inflammatory arthritis and for the analysis of therapeutic agents. Current therapy has a goal of complete and long-lasting remission but, typically, only partial remission is achieved and frequent relapses or even non-response are common. Both immune-modulating and anti-rheumatic medications have severe side effects, some of which could be dangerous or even life-threatening. Herbal medicines are an alternative source for relieving symptoms in patients with RA as well as for overcoming the disadvantages associated with current therapy techniques. Interestingly, a wide range of medicinal plants provides a huge resource for such anti-arthritic active principles. This review will throw the light on the current animal models and various active principles derived from plants that have shown promise as anti-arthritic agents in latest years and will outline their prospective action mechanism.

Keywords | Rheumatoid arthritis, Medicinal plants, Alternatives, Management