Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 7(6): 508-515
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Ahmed A. Alkhalidi1, Suha Aljumaily1, Maisaa G. Taher2*, Zahid I. Mohammed1

1Department of public health ,collage of Veterinary Medicine, University of Diyala; 2Department of Pathology, College of Medicine, Diyala University, Iraq.

Abstract | This study was carried out to find the pathological changes on mice infected experimentally with Absidia spp isolated from cats, and immune modulator effects of β-glucan compound against Absidia spp. To achieve the goal, Forty mice were divided randomly into two groups, 1st group (n=20 mice) fed on diet supplement with 100mg/kg diet of β-glucan for 5weeks. 2nd group (n=20 mice) was served as a control group. The two groups were challenged with 1×107fungal cells/ml I/P of virulent Absidia spp. The result showed that 5out of 20 mice in the first group died at 1-3 days and 14 out of 20 mice in the second group. The level of protection observed in the mice of the first group showed in 75% of infected immunized mice, where 30% protection was reported in mice of the second group. The histopathological examination in the control group of mice showed acute suppurative inflammation in the examined organs at 24-72 hour post infection with necrosis, inflammatory cells infiltration and the mold and hyphae were observed in the liver, kidney, spleen and lung, as well as moderate to mild pathological lesion at day 45 post-inoculation, Mononuclear cells and neutrophils were seen in most examined organs of the 1st group. The present study was concluded that the Absidia spp. causes high pathological lesions and the β-glucan as immunomodulater alone provided partial protective immunity against lethal doses of Absidia spp.

Keywords | β-glucan, Pathological lesions, Fungal, Absidia spp, Immunomodulater