Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 7(6): 441-446
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Ghassan H. Jameel1, Zahid I. Mohammed1*, Maisaa G. Taher2, Audy Hisham Bahloul3,Sufyan Taha Lateef3

1University of Diyala, College of Veterinary Medicine, Diyala , Iraq; 2University of Diyala, College of Medicine, Diyala, Iraq; 3University of Diyala,Department of Scientific Affairs, Iraq.

Abstract | Ivermectin drug used in the treatment of endo and ecto parasites in animals, but in this study was used to treat Bovine ocularsquamous cell carcinoma (BOSCC) at a dose 200 mg /Kg body weight. Forty cattle were used in this study in a period from January 2014 to December 2015. The result of this study was revealed significant increase (P≤0.05) in the mean of total white blood cells count (5.39 ± 1.052) cell/mm3 before treatment and reach to (6.49 ± 0.422)cell/mm3 after treatment and the mean of lymphocyte rate (34.5 ± 3.20)% before treatment and reach to (60.6±10.83)% after treatment. Also, there was significant depression (P≤0.05) in the means of neutrophils and monocytes rates (59.4 ±4.52)% , (4.3 ±1.40)% before treatment compare with percentage of cells after treatment were (34.4 ±9.56)% , (2.2 ± 1.15)% respectively. The result showed significant (P≤0.05) decreased in the TNF-Alpha level (10.1 ± 1.1) ng/L in after treatment, while was (14.9 ± 0.48) ng/L before treatment compare with the control group was (6.5 ± 3.1) ng/L. Sixteen cattle were recovering from sum of twenty cattle in the treated group, the cure rate reaches to 80% with sign of loss the cancer mass size without any side effect on the animals. The Ivermectin could be a drug to treat BOSCC with a 80% cure rate.

Keywords | TNF-alpha, Ivermectin, Squamous cellcarcinoma