Advances in Animal and Veterinary Sciences

Case Report
Adv. Anim. Vet. Sci. 1 (1S): 23 - 28. Special issue-1 (Veterinarians approaches for safeguarding animal health and production)
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Shoor Vir Singh1*, Saurabh Gupta1, Pravin Kumar Singh2, Ajay Vir Singh2, Jagdip Singh Sohal3, Naveen Kumar1, Avnish Kumar4, Kundan Kumar Chaubey1, Brajesh Singh1
1Microbiology Laboratory, Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO – Farah, Mathura, Uttar Pradesh, India; 2National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra, Uttar Pradesh, India; 3Canadian Food Inspection Agency, 3400 W Casavant, St. Hyacihthe (QC), Canada– J2S 8E3; 4School of Life sciences, Khandari, Agra, Uttar Pradesh, India
*Corresponding author:;

Study reports therapeutic management of clinical to advance clinical Bovine Johne’s disease in a young male calf and an adult dairy cow of native Hariana breed in Mathura district. Calf (14 months old) suffering from symptoms of clinical bovine Johne’s disease (weakness and stunting without diarrhoea) was negative for MAP infection in fecal microscopy, blood PCR and ELISA, An adult cow (144 months old) a case of advance clinical BJD (suffering from non–treatable diarrhoea for last 3 years and weakness) was positive in ELISA and negative in microscopy and blood PCR tests. After exhausting all possible therapies, both the animals were vaccinated with 2 ml of ‘indigenous vaccine’ made from ‘Indian Bison Type’ biotype of Mycobacterium avium subspecies paratuberculosis (strain S 5) of goat origin, as last option. ‘Indigenous vaccine’ effectively helped in the management of clinical JD in case of calf however immune response was limited and not sufficient in the cow to fully recover from advance clinical JD. The study besides exhibiting therapeutic potential of goat based ‘indigenous vaccine’, also underlined the critical role of nutrition in response to vaccination and in management of chronic infections, just as it hastens or delays the precipitation of disease from sub–clinical to clinical or advance clinical stage. The study also exposed limitation of laboratory tests used for the diagnosis of clinical BJD.

Key Words: Cow; Johne’s disease, Indigenous vaccine, Therapeutic management, Control