Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 2 (10): 543 - 548
http://dx.doi.org/10.14737/journal.aavs/2014/2.10.543.548
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Samiran Mondal1, Tathagata Sengupta3, Saktipada Pradhan1, Rabindra Nath Hansda1, Partha Sarathi Mandal1, Ruchi Tiwari2, Sunit Kumar Mukhopadhayay1
1Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences, 37 KB Sarani, Kolkata- 70037; 2Department of Veterinary Microbiology, College of Veterinary Sciences, Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwa Vidyalaya Evum Go-Anusandhan Sansthan (DUVASU), Mathura (U. P.)–281001; 3TCG Lifesciences, Saltlake, Kolkata-700091.

*Correspondence | Samiran Mondal, West Bengal University of Animal and Fishery Sciences, Kolkata; Email: vetsamiran@gmail.com

Abstract
Memories are thought to be encoded by modification of synaptic strength i.e. Long term potentiation (LTP), a widely considered one of the major cellular mechanisms behind the process of learning and memory. To evaluate the synaptic strength after being exposed to acetamiprid, a neonicotinoid insecticide, in animal and human, this study was taken up. In this regard, the study was conducted on 24 healthy male Sprague Dawley rats divided into two groups each having 12 animals. Group I was control and Group II served as acetamiprid treated test group. Test group animals, treated with one week exposure of acetamiprid, showed impaired learning and memory in both behavioural and functional assay tested in this experiment. Study results concluded that regular exposure to insecticide like acetamiprid impaired learning capacity and memory in rats by disrupting synaptic strength at neuronal junction of brain. Although this insecticide had shown impairment in learning and memory processes yet it remains to be learned that how this group of chemicals act. Further research need to be performed in the future to support the evidence and literature against effect of insecticide exposure in rats and in other species as well.

Keywords: Long term potentiation, Learning, memory, Acetamiprid, Electrophysiology, Hippocampus,
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