Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(11): 2005-2013
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Abdelmoneim A. Ali, Nahla AG. Ahmed Refat, Mohamed M.M. Metwally, Mohammed S. Sobh*

Pathology Department, Faculty of veterinary medicine, Zagazig University, Sharkia, Zagazig 44159, Egypt.

Abstract | Few studies and very limited published data concerning the spread of neoplasia among Equidae in Egypt are available, therefore, the present study was carried out to investigate the prevalence and types of neoplasia among Equidae in Sharkia Governorate, Egypt, and to assess the efficacy of some available biomarkers as a diagnostic tools. This work was investigated 35 clinical cases of equine neoplasms (23 donkeys, 10 horses, and 2 mules) out of 1513 total examined cases admitted from different clinics in Sharkia Governorate, from May 2019 to October 2020. Depending upon gross and histopathological findings; the neoplastic growths include 12 cases of sarcoids, 9 cases of fibroma, 4 cases of squamous cell carcinoma, 3 cases of papilloma, 2 cases of fibropapilloma, 1 case of fibrosarcoma,1 case of myxoma, 1 case of of myxosarcoma, 1 case of myxoid liposarcoma, and 1 case of ovarian teratoma. Immunohistochemically, cytokeratin5 (CK5), MDM2, and S100 biomarkers were used to confirm the diagnosis of certain neoplasms. The Overall prevalence of equine neoplasms was 2.31 %. The diagnosed cases were linked with animal species and sex and the significance (p < 0.05) of differences among age, seasons, and location of the neoplasms were evaluated. The prevalence rates in domestic donkeys, horses, and mules were 2.66 %, 1.94%and 1.22% respectively. The rate of affected animals over 3 years was (3.38 %) in comparison with animals less than 3 years (0.19 %). Females (2.64%) were more affected than males (2.28%)   and mules (1.42%). The prevalence rate was 5.56% in summer, 1.6 % in spring, 1% in autumn, and 0.85 % in winter. A higher rate of neoplasms was reported in extremities and trunk (1.25%), 0.52% in the head, neck, 0.19% back, ventrum,  0.19% in eye, related skin, 0.13 % in genital organs.

Keywords | Egypt, Neoplasms, Equine, Histopathology, Immunohistochemistry.