Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(11): 1978-1988
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Amany E. Nofal1*, Reda M. Fayyad2

1Zoology Department, Faculty of Sciences, Menoufia University, Egypt; 2Pharmacology Department, Faculty of Medicine Al-Azhar University, Egypt.

Abstract | Toxicity and resistance to chemotherapeutic drugs remain major obstacles to successful therapy. We researched the ameliorative impacts of combining natural agent-like resveratrol with a chemotherapeutic drug-like 5-fluorouracil to improve its efficacy and reduce its side effect severity. Our results indicated that RES and 5-FU had a therapeutic impact against Diethylnitrosamine-induced HCC, and the best result was gained when both had been used together, they retain normal liver structure and functions also decreased the cytotoxic impact of 5-FU. RES remarkably reduced most of the effects induced by DEN, as they suppressed the significant increased relative liver weight, the hepatic nodules number and their relative volumes, the raised levels of serum liver function tests, and increased the depression of T. protein, albumin, globulin, liver homogenates antioxidants indicating their antioxidant effect. Furthermore, it showed alterations in the expression of the levels of some inflammatory cytokines in serum, and immunoreactivities (Bax, CK18, and CA19-9) in the liver sections of the HCC group when compared with other groups. Dual-treatment of the phytochemical substance and the antitumor drug had an observantly therapeutic and immune-modulatory efficacy against HCC as they together have less toxicity than pharmaceutical agents.

Keywords | Chemotherapeutic Drug, Hepatocellular Carcinoma, Inflammatory Cytokines, Resveratrol, 5-Fluorouracil