Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(11): 1895-1907
Http://dx.doi.org/10.17582/journal.aavs/2021/9.11.1895.1907
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Sarah Mohamed Yousry1, Ragia Ali Mahmoud Taha1, Hossny Awad El-Banna2, Shimaa R. Emam2*

1Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls) AL-Azhar University, Cairo, Egypt; 2Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo 12613, Egypt.

Abstract | Congestive heart failure (CHF) is a chronic progressive condition associated with high mortality. The curative and prophylactic role of sage oil on Isoprenaline (ISO) induced CHF were evaluated in rats and compared with the reference digoxin. Sage oil was used at two doses of 50and100mg/kg. Blood samples werescreened for cardiac markers (CK-MB and cTnI) and inflammatory marker (TNF-α). Heart tissues were used for heart index calculation, measurement of oxidative stress markers (MDA and NO, TAC), histopathological examination for Hematoxylin and Eosin, Masson stain for collagen fiber content and immunohistochemical stain for caspase 3 as a marker of apoptosis. Administration of sage oil as a prophylactic measure significantly improves ISOinducedalterations in most of parameters measured in a dose dependent manner. Pretreatment of ISO treated rats with sage oil 50and100mg/kg showed partial amelioration of CHF in a dose dependent manner with significant lower effectthandigoxin. Further investigation for sage oil curative effect on CHF is recommended.

Keywords | Isoprenaline, Saga oil, Congestive heart failure, Curative, Protective