Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(11): 1800-1809
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George Bazekin1*, Evgeny Skovorodin1, Ilgiz Dolinin1, Ildar Gatiyatullin1, Ivan Chudov1, Asiya Ezhkova2

1Department of Morphology, Pathology, Pharmacy and Non-Communicable Diseases, Federal State Budget Educational Institution of Higher Education “Bashkir State Agrarian University”, 50-letia Octyabrya str., 34, Ufa, 450001, Russian Federation; 2Department of Physiology and Pathological Physiology, Federal State Budgetary Educational Establishment of Higher Education “Kazan State Academy of Veterinary Medicine named after N.E. Bauman”, SibirskiyTract str. 35, Kazan, 420029, Russian Federation.

Abstract | This paper aims to study the influence of new immunostimulants of tissue and plant origin on the morphological characteristics of the immune system the dynamics of serum immunoglobulins. The conducted research revealed the beneficial effect of glycyrrhizic acid (GA) on the body of sick animals, promoting their growth and development, improving animals’ clinical and physiological parameters. GA showed a positive effect on the cellular and humoral factors of natural resistance of calves with bronchopneumonia. Thus, GA activates biochemical processes and immune response aimed at the coordinated use of energy resources. It results in a favourable outcome of the disease due to activated metabolism and positively affects calf growth and development. Biostimulator Nucleostim is a purified extract of bovine spleen containing at least 1 mg/ml of low molecular weight peptides. At the end of the experiment, the survival rate of the experimental group of fowl treated with nucleostim increased to 88% compared to 72% of the control group. Nucleostimbiostimulant as a feed additive for chickens restores the histological architecture of the thymus with differentiation of the well-distinguished cortex and the medulla. It increases the mitotic activity of thymocytes, improves blood supply to the organ.

Keywords | Calves, Glycyrrhizic acid, Immunoglobulins, Morphology, Nucleostim