Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(10): 1576-1584
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Suliat A. Salami1*, Adekunle B. Rowaiye1, Samuel K. Ogoina2, Ayuba A. Amos2, Solomon O. Oni2, Titilayo M. Asala1, Doofan Bur1, Terna H. David2

1National Biotechnology Development Agency, Federal Capital Territory Abuja, Nigeria; 2Bioresources Development Centre, Isanlu, Kogi State Nigeria.

Abstract | The effects of the oral administration of aqueous extract of Pleuroteus tuber-regium sclerotium (PTRSE) in drinking water on growth, serum metabolites and histomorphology parameters were examined using 72 cross-bred growing rabbits. Eighteen rabbits each were allotted to 4 treatments with; 0, 500, 750 and 1250 mg PTRSE per liter (mg/L) in drinking water per day. The experiment lasted for 60 days. Data collected were subjected to one-way analysis of variance (ANOVA). The results revealed an improvement in the live weight (P<0.01), weight gain (Linear (L), Quadratic (Q): P<0.01), feed conversion ratio (L, Q:P<0.01), water intake (L, Q:P<0.01) and extract intake (L, Q:P<0.01) following increasing levels of PTRSE in drinking water. Oral administration of 750 mg/L PTRSE in drinking water resulted in reduced (P<0.01) serum total cholesterol, low-density lipoprotein, very low-density lipoprotein, creatinine and alkaline phosphatase; and increased cecal villi height (L, Q:P<0.05) and apical width (Q:P<0.05). Pathological indicators suggested damages to hepatic tissues in rabbits on 1250 mg/L PTRSE. In conclusion, the oral application of 750 mg/L PTRSE in drinking water can improve the growth, cholesterol profile and absorptive capacity in growing rabbits without imposing any detrimental effect.

Keywords | Intestinal morphology, Mushroom extract, Pathology profile, Serum analytes