Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 9(7): 1071-1077
Http://dx.doi.org/10.17582/journal.aavs/2021/9.7.1071.1077
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Walaa M.S. Ahmed1, Naglaa M. Abdel-Azeem2, Marwa A. Ibrahim3*, Nermeen A. Helmy4, Abeer M. Radi5

1Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt; 2Department of Animal and Poultry Management and Wealth Development, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza Egypt; 4Department of Physiology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt; 5Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.

Abstract | The protective role of cinnamon oil (C. oil) on the liver and renal functions, Nrf2 gene expression and histopathology in the rat following administration of deltamethrin (DM) was investigated. Rats were divided into 4 groups, rats of the 1st group (control) were given saline, while the 2nd group was given C. oil (100 mg/kg B.W) and 3rd group was administrated DM (6 mg/kg B.W) orally. The 4th group was given C. oil and DM. All treatments were given orally daily for 3 weeks. Blood biochemical parameters and histopathological study for liver and kidney tissues were conducted. Administration of DM caused a significant elevation in alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities, cholesterol, triglyceride, urea and creatinine concentrations and upregulates the Nrf-2 gene expression. While the total protein, albumin and globulin levels were not changed. It was noticed that concomitant oral administration of C. oil plus DM significantly decreases the activities of these enzymes, cholesterol, triglyceride, urea and creatinine concentrations. Also, C. oil resulted in down-regulation of Nrf-2 expression and ameliorated the histopathological alterations in hepatic and renal tissues. In conclusion, Co-administration of C. oil attenuates the hepato-nephrotoxic effects of DM and this may be through decreasing oxidative stress.

Keywords | Cinnamon oil, Deltamethrin, Kidney, Liver, Nrf-2 gene, Histopathology.