Advances in Animal and Veterinary Sciences

Research Article
Adv. Anim. Vet. Sci. 7(s1): 33-39
Http://dx.doi.org/10.17582/journal.aavs/2019/7.s1.33.39
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Vladimir Vasilyevich Salautin*, Vitaly Ivanovich Gorinsky, Grigory Prokofievich Demkin, Alexey Vyacheslavovich Molchanov, Nikolai Aleksandrovich Pudovkin, Ivan Yurevich Domnitsky, Svetlana Evgenevna Salautina

Saratov State Agrarian University named after, Saratov, st. Sokolovaya 335, (8452) 69-25-31, N.I. Vavilova.

Abstract | The aim of the study was to neutralize the toxic effect of chemotherapy, with simultaneous activation of immunological reactions mediated by T and B lymphocytes, natural killers and macrophages. When conducting a set of diagnostic measures, the anamnestic data, the results of physical examination, electrocardiographic, ultrasound and X-ray studies were taken into account. The article presents the results of studies on the effect of palliative combined system immune chemotherapy with Ligfol and Fluorouracil on mammary gland cancer relapse in dogs in incurable cases. Hematological and biochemical blood tests and urinalysis were performed in all animals. For the classification of malignant neoplasms, tumor, nodus and metastasis (TNM) classification was modified, taking into account specific features of dogs. It has been established that a course of the combined systemic immuno-chemotherapy with Ligfol and Fluorouracil in females with recurrent mammary gland cancer, according to our proposed scheme, has low overall and hematological toxicity, which does not require delay in treatment, reduction of the dose of chemotherapy drug, and corrective therapy. In addition, the proposed treatment strategy allows achieving stabilization of the tumor process.

Keywords | Mammary gland cancer, Chemotherapy, Ligfol, Fluorouracil, WBCs, RBCs, Platelets