Figure 26-37
Canine peripheral nerve sheath tumor, skin, dog. The spindle neoplastic cells are arranged in wavy bundles, palisades and whorls. HE. 27) Canine peripheral nerve sheath tumor, skin, dog. The neoplastic cells show moderate immunolabelling. IHC for glial fibrillary acidic protein (GFAP). 28) Canine hemangioma, skin, dog. The tumor is formed of variably sized blood spaces containing erythrocytes and lined by a single layer of uniform endothelial cells. HE. 29) Canine hemangiosarcoma, skin, dog. The plump neoplastic endothelial cells are forming irregular blood spaces and filling the trabeculae in between. HE. 30) Canine hemangiosarcoma, skin, dog. The neoplastic cells show intense immunolabelling. IHC for vascular endothelial growth factor (VEGF). 31) Canine rhabdomyosarcoma, skin, dog. The neoplasm is formed of numerous pleomorphic neoplastic cells with frequent atypical mitosis and few skeletal muscle bundles. HE. 32) Canine epitheliotropic lymphoma, skin, dog. The neoplastic T-cells are infiltrating the dermis with increased affinity for epidermis and adnexal epithelium. HE. 33) Canine epitheliotropic lymphoma, skin, dog. The neoplastic cells show intense immunolabelling. IHC for CD3. 34) Canine mast cell tumor, skin, dog. The neoplastic mast cells are round, monomorphic with abundant basophilic granules. HE. Inset: Canine mast cell tumor, skin, dog. The metachromatic granules of mast cells are dispersed in the cytoplasm. Toluidine blue. 35) Canine cutaneous histiocytoma, skin, dog. The dermis is densely packed by slightly pleomorphic cells with little or no stroma. HE.
36) Canine sebaceous hamartoma, skin, dog. Proliferating mature sebaceous glands are found in the mid dermis with marked peri-glandular fibrous tissue proliferation. HE. 37) Canine transmissible venereal tumor, skin, dog. The neoplasm is formed of uniform round cells with vacuolated cytoplasm as well as frequent mitotic figures and scanty stroma. HE.