Influence of Adjuvants on Innate and Adaptive Immune Systems. Source Kensil et al., 2004, with some modifications.  

Functions of vaccine particle preparations in regulating vaccine systemic delivery and presentation to immune cells. Vaccines particles in the size range of 20 to 100 nm are particularly transported into the lymphatic vessels towards the Lymph nodes (LNs), whereas smaller molecules are distributed into the systemic circulation with inferior lymphatic uptake. Bigger particles become entombed in tissue and incline to be deposited close to the site of injection. (1) Vaccines particles comprising of both antigen and the danger signals can be coded by the liver these vaccine components are presented to the APC, permitting the stimulation of PRRs selectively in cells that have received antigen. (2) Enormous population of antigen on the surface of vaccines particles augments cross-linking of antigen receptors on specific B cells. Source: Moyer et al., 2016 with some modifications.