South Asian Journal of Life Sciences

Research Article
S. Asian J. Life Sci. 3 (1): 22 - 41
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Soon Hong Kwan1, Saringat Baie2, Nornisah Mohammed2, Mohd Nazri Ismail1*

1Doping Control Centre, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia; 2School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia.

*Correspondence | Mohd Nazri Ismail, Doping Control Centre, Universiti Sains Maalaysia, 11800, USM, Penang, Malaysia; Email:

Channa striatus is a carnivorous freshwater fish that is commonly consumed among Malaysians. The fish is known to contain compound(s) that can accelerate the wound healing process in humans, but the attributes of these compound(s) are yet to be clarified. In the current study, we have performed a thorough proteomic profiling of spray -dried and freeze-dried C. striatus water extracts using high-sensitivity liquid chromatography tandem mass spectrometry. Other than the analysis of whole sample, both samples were also fractionated in order to maximise protein detection. About 137 and 194 proteins were identified in spray dried and freeze dried samples, respectively. Actin, myosin, tropomyosin, calcium ion-related protein and collagen are among the proteins that have been identified, and which are suspected to be involved in the wound healing process. A high number of uncharacterised proteins were also detected, which suggested that there are still many fish proteins with unknown functions in C. striatus. In the future, the identified proteins can be isolated and further studies are required for a better understanding on the wound healing property of C. striatus.

Keywords | Channa striatus, Fish, Mass spectrometry, Proteomics, Wound healing

Editor | Muhammad Nauman Zahid, Quality Operations Laboratory, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Received | May 20, 2015; Revised | September 27, 2015; Accepted | September 29, 2015; Published | December 17, 2015

Citation | Kwan SH, Baie S, Mohammed N, Ismail MN (2015). Proteomic profiling of Freeze- and spray-dried water extracts of Snakehead fish (Channa striatus): In search of biomolecules for wound healing properties. S. Asian J. Life Sci. 3(1): 22-41.

ISSN | 2311–0589

Copyright © 2015 Kwan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.