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Journal of Infection and Molecular Biology

Research Article
J. Inf. Mol. Biol. 6(2): 28-35
Http://dx.doi.org/10.17582/journal.jimb/2018/6.2.28.35
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Golnoosh Taghiabadi1,2, Tayebe Talebzade3, Donya Altafi4, Iman Alsadat Hosseini4, Hamed Hojatiyan4, Morteza Taghizadeh5, Massoud Houshmand6, Soha Sadeghi2,4,7*

1Department of biology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran; 2Department of Molecular genetics, Research Institute of Nikan Royesh Gene, Karaj, Iran; 3Department of Microbiology, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran; 4Department of Cellular and Molecular Biology, Nour Danesh Institute Of Higher Education, Isfahan, Iran; 5Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran; 6Department of Medical Genetics, National Institutes for Genetic Engineering and Biotechnology, Tehran, Iran; 7Department of Medical Genetics, Laboratory of National Institutes for Genetic Engineering and Biotechnology, Tehran, Iran.

Abstract | Background: Alopecia areata (AA) is an autoimmune disease, leading to disfiguring hair loss that susceptibility loci and the genetic basis of AA have been largely unknown. Objective: The aim of this study was the scrutiny the susceptible genes of Alopecia areata amongst patients and healthy adult in Iranian populations. Methods: four variants polymorphisms (rs1701704, rs10760706, rs9275572, rs694739) were studied by Tetra Arms PCR, Sequencing methods in 200 Iranian healthy adult blood donors and 200 patients with Alopecia Areata (AA). Results: Results were showed that 4 SNPs had P-values <0.05 for association with Alopecia areata. 3 of 4 SNPs, was demonstrated significant association in analyses 100 AT/AU cases versus 100 AA, which is localised in IKZF4, STX17, PRDX5, HLA-DQB1 (rs1701704, rs10760706, rs694739 and rs9275572 respectively). Conclusions: In this study, 3 of 4 SNP-associated loci were associated significantly with association with the development of Alopecia areata. In another word, the presence of them may be a contributing factor for prognosis of the development of the disease to Totalis and Universalis..

Keywords | Alopecia Areata (AA), Alopecia Universalis (AU), Alopecia Totalis (AT), autoimmune disease