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Journal of Infection and Molecular Biology

Review Article
J. Inf. Mol. Biol. 3 (1): 19 - 23
http://dx.doi.org/10.14737/journal.jimb/2015/3.1.19.23
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Hira Paracha1, Tanveer Hussain2, Muhammad Zahid Tahir3, Atiya Yasmeen2, Muhammad Tariq Pervez1, Ali Ahmad Sheikh4, Abbas Haider5, Rizwan Ali2, Waqas Ahmad Khan6
1Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, 54000; 2Virtual University of Pakistan, Lahore; 3Department of Theriogenology, University of Veterinary and Animal Sciences, Lahore, 54000; 4University Diagnostic Lab, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.; 5Livestock and Dairy Development Department, Punjab, Pakistan; 6University of Sargodha, Pakistan.

*Correspondence | Tanveer Hussain, Virtual University of Pakistan, Lahore; Email: tanveer.hussain@vu.edu.pk

Abstract
Major histocompatibility complex (MHC) is a large family of genes present in various vertebrates and is well known for the diversity of its alleles. These genes play an important role in the recognition of foreign antigens and mediating an immune response. MHC is classified as Class I, II and III molecules based on their molecular weights as well as differences in their cellular distribution and function. DRB3 gene is a member of MHC Class II and is known to show extensive polymorphism. This gene is being used as marker in phylogenetic and molecular genetics. This paper is aimed to review the role of DRB3 gene in goats.

Keywords | MHC, DRB3, Polymorphism, Immune response, Ruminants to maintain a sustainable dairy industry in the future