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Journal of Infection and Molecular Biology

Research Article
J. Inf. Mol. Biol. 2 (3): 32 - 34
http://dx.doi.org/10.14737/jimb.2307-5465/2.3.32.34
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Bindi Das Mohandas Sulaja*, Ugam Kumari Chauhan
Centre for Biotechnology Studies, A.P.S University, Rewa, MP, India.
*Corresponding author: bindidas_ms@yahoo.com

ABSTRACT
Tuberculosis (TB) in children is an important cause of morbidity and mortality worldwide. There is much risk of severe disease and death among young than adults, therefore, the pediatric tuberculosis remains a public health emergency. Vitamin D receptor (VDR) mediates the immunological function of vitamin D3 which activates macrophages and its deficiency concerned to the risk of TB. So polymorphisms in VDR gene may influence the function of vitamin D and susceptibility to TB. This study is to investigate the existence of possible association between VDR Fok I polymorphism (rs 10735810) and pediatric pulmonary tuberculosis in Madhya Pradesh of central India, using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP). The VDR Fok I polymorphism showed statistically significant association with pediatric pulmonary TB in central Indian population. The FF genotype and F allele showed lower risk to TB in children while the heterozygous Ff genotype could be associated with pathophysiology of pediatric TB (OR = 2.413). The ff genotype was statistically non-significant as the frequency of this genotype was very less in both cases (5.97%) and control (2.5%).

Key Words: Fok-I, Genotype, Polymorphism, Polymerase Chain Reaction (PCR), Tuberculosis, Vitamine D Receptor(VDR)