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Journal of Infection and Molecular Biology

Review Article
J. Inf. Mol. Biol. 2 (2): 26 - 29
http://dx.doi.org/10.14737/jimb.2307-5465/2.2.26.29
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Asmarani Kusumawati1,2*, Tenri Ashari Wanahari3, Rizqa Febriliany Putri3, Basofi Ashari Mappakaya3, Issabellina Dwades Tampubolon2
1Departement of Reproduction, Faculty of Veterinary Medicine, Gadjah Mada University, Jalan sekip unit II, Yogyakarta, 55281 Indonesia; 2Centre of Biotechnology Study, Gadjah Mada University, Jalan teknika utara, Yogyakarta, 55281 Indonesia; 3Faculty of Medicine, Sebelas Maret University, Jalan Ir. Sutami 36 A, Surakarta, 57126 Indonesia
*Corresponding author: kartapati_2008@yahoo.com

ABSTRACT
The pathogenic agent of Jembrana disease is a virus which was consequently named Jembrana disease virus (JDV). JDV was definitively defined as a member of the subfamily of lentiviruses of the family of Retroviridae. The genome of JDV is a linear single–stranded RNA, 7732 nucleotides in length. It contains the structural genes gag, pol and env which encode structural and enzymatic proteins that make up infectious viral particles and flanking long terminal repeats (LTR) that characterize all retroviruses. Accessory genes of JDV include tat, rev and vif that are typical of lentiviruses and which are required for the production of regulatory proteins. Products of most accessory genes have been shown to play important roles in viral replication and pathogenesis. The genome of BIV, another bovine lentivirus, is the most related lentivirus to JDV. Though the two bovine lentiviruses have to be considered as two distinct entities as the two viruses are sufficiently different.

Key Words: Jembrana Disease, Lentivirus, Structural gene, Accessory gene, Bovine Immunodeficiency Virus, Retrovirus