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Journal of Infection and Molecular Biology

Review Article
J. Inf. Mol. Biol. 1 (4): 52 - 57
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Muhammad Zubair Shabbir1, Ahsan Nadeem Malik2, Abdul Wajid3, Shafqat Fatima Rehmani1, Muhammad Munir4*
1Quality Operations Laboratory, University of Veterinary and Animal Sciences, Lahore 54600, Pakistan; 2Veterinary Officer, Poultry Research Institute, Livestock and Diary Development Department, Punjab; 3Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore 54600, Pakistan; 4The Pirbright Institute, Compton Laboratory, Newbury, Berkshire, RG20 7NN, UK *Corresponding author: drmunir.muhammad@gmail.com

ABSTRACT
Newcastle disease, caused by avian paramyxovirus serotype–1, is one of the deadly diseases of poultry around the globe. The disease remains endemic and poses serious consequences annually to the Pakistani poultry industry and the situation is aggravated by poor biosecurity measures. Currently, LaSota vaccine strain is being used as live attenuated vaccines. This vaccine protects the birds to a certain level, however, is not fully protective against all genotypes of NDV (e.g. VII) and doesn’t prevent the virus secretions. In last few years, several new genotypes have been identified in Pakistan, Madagascar, and Nigeria highlighting the evolution of the virus in intense poultry rearing system. Due to evolutionary trends of the viruses, validated PCR are failing to detect the novel and old strains of NDV which adds another layer of complication. Given the fact that NDV is an excellent vaccine vector, it is required to construct genotype matched vaccines in the respective endemic countries for not only protection but also to minimize the secretion of the virus. These recombinant vaccines along with good husbandry conditions are expected to safeguard the poultry especially in developing countries.

Key Words: Newcastle disease, Poultry, Vaccine vector, Biosecurity measures, Genotypes