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Advances in Pharmaceutical and Ethnomedicines

Research Article
Adv. Pharm. Ethnomed. 5(1): 8-15
Http://dx.doi.org/10.17582/journal.ape/2017/5.1.8.15
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Abdallah H. Fathy1, Mohamed A. Bashandy1, Ahmed M. Mansour2, Khaled Sh. Azab3, Samir AE. Bashandy4

1Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt; 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt; 3Department of Radiation Biology, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt; 4Department of Pharmacology, National Research Center, Cairo, Egypt.

Abstract | Chemotherapy and radiotherapy are among the traditional methods used in cancer treatment and they cause toxicity to normal cells. The purpose of the present study is to determine the possible hepatoprotective role of olive oil (7 g/kg) with fig (1 g/kg) and date-palm fruit (1 g/kg) extracts (OFD) together as potent antioxidants in alleviating the toxicity of doxorubicin (DOX) and/or gamma radiation in albino Wistar rats. We injected the rats with DOX (2.5 mg/kg, i.v.) and/or exposed the rats to irradiation (2 Gy, whole body) weekly, for four consecutive weeks. We used the antioxidant treatments daily via oral gavages for two weeks protection period and during the experiment (4 weeks). The DOX and/or irradiated groups recorded severe depletion of antioxidant parameters (superoxide dismutase, catalase and reduced glutathione) as well as increased thiobarbituric acid reactive substances, advanced oxidation protein products, and alterations of liver function parameters (transaminases, alkaline phosphatase, gamma glutamyl transferase, total protein, albumin and bilirubin) as compared with control rats. Administration of OFD to DOX and/or irradiated rats significantly ameliorated the oxidative stress markers and liver function parameters as compared with DOX and/or irradiated rats. In conclusion, the olive oil with fig and date-palm fruit extracts together could be used synergistically to decrease the bad side effects of chemotherapy and radiotherapy.

Keywords | Olive oil, Fig fruit extract, Date-palm fruit extract, Doxorubicin, Gamma radiation, Oxidative stress.