Journal of Animal Health and Production

Research Article
J. Anim. Health Prod. 9(s1): 62-68
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Abdel Moneim A. Ali1, Mahmoud F. Fahmy1, Mohamed M. Metwally1, Hend A. Azazy2, Rehab E. Mowafy2*

1Pathology Dep. Faculty of Veterinary Medicine - Zagazig University; 2Animal Health Research Institute (ACR), Dokki, Gizza, Egypt.

Abstract | Despite its less prevalence compared to other mycotoxins, ochratoxin-A (OTA) is considered the most powerful toxin causes avian ochratoxicosis. Therefore, the aim of this study was to evaluate the protective role of antimycotoxins cholestyramine and oxihumate against the toxicity of OTA. To fulfil that, one-day-old chicks (n=64) were randomly allocated into four groups (16 chicks per group); group-1(basal diet + ochratoxin-A), group-2 (basal diet + ochratoxin-A + cholestyramine), group-3 (basal diet + ochratoxin-A + oxihumate), and group-4 (basal diet). After 36 days, livers, kidneys and muscles were harvested for histopathological studies as well as residual analysis of OTA. Nephrotoxicity was the most detected lesion among chickens of group-1. The intensity of the lesions-related toxicity was significantly (P˂0.05) reduced in the treated groups (group-2 and group-3). OTA residues were significantly reduced in the kidneys (P˂0.05), livers (P˂0.05), and muscles (P˂0.05) in both treated groups in comparison with that of group-1. In conclusion, both cholestyramine and oxihumate ameliorate the tissue deteriorations of OTA in chickens, whereas cholestyramine was more effective than oxihumate.

Keywords | Ochratoxin, Cholestyramine, Oxihumate, Mycotoxicosis, Chicken