Journal of Animal Health and Production

Case Report
J. Anim. Health Prod. 9(1): 47-51
Http://dx.doi.org/10.17582/journal.jahp/2021/9.1.47.51
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Rasmini Wickrama Surendre1, Mohd Farhan Hanif Reduan1*, Sabri Jasni1, Sujey Kumar Rajendren2, Nadiah Syuhada Roslan3, Intan Noor Aina Kamaruzaman1, Nurshahirah Shaharulnizim2, Muhammad Luqman Nordin2

1Department of Paraclinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia; 2Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia; 3Universiti Malaysia Kelantan Veterinary Clinic, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia.

Abstract | ­Melanoma or malignant melanoma is an abnormal production of melanocytes in a dysregulated manner leading to the formation of a nodule, mass or other types of lesion. In this report, we describe the rare occurrence of malignant cutaneous melanoma as melanomas of haired skin origin are generally known to be benign and less aggressive compared to its mucocutaneous counterpart. A thirteen-year old, spayed female Shih Tzu Mix was presented to Universiti Malaysia Kelantan Veterinary Clinic with a history of a bleeding mass on the left scapular region. Upon physical examination of the integumentary system, there were generalized brownish to greyish and black macules of varying sizes as well as soft, black nodules with a smooth surface located at the right lateral trunk region and at the caudal-proximal region of the tarsal joint. The mass on the left scapular region appeared alopecic, firm and cauliflower-like with an ulcerating centre. Complete blood count revealed a mild to moderate lymphopenia and neutrophilic granulocytosis. The cytological evaluation revealed pleomorphic neoplastic cells characterized by spindle to round phenotypes, having dark, dust-like intracytoplasmic melanin granules with multiple prominent nucleoli and mitotic figures. The patient was treated via surgical excision of the ulcerating tumour. Histopathological examination of the excisional biopsy revealed pagetoid melanocytosis, spindle and round neoplastic cells with high mitotic index, marked tumour lymphoplasmacytic infiltration and intracytoplasmic melanin pigments. Discretely scattered neoplastic melanocytes and melanin pigments were also observed within the subcutaneous layer, indicating tumour infiltration. In conclusion, the diagnosis of cutaneous melanoma was made based on cytological and histopathological findings and treatment was done via surgical excision.

Keywords | Cutaneous melanoma, Malignant, Cytology, Histopathology, Surgical excision