Journal of Animal Health and Production

Research Article
J. Anim. Health Prod. 8(3): 93-100
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Asmaa Abdallah Darwish1, Mohamed Fahmy Eldakroury2*

1Animal and Poultry Health Department, Animal and Poultry Health Division, Desert Research Center, Cairo, Egypt; 2Department of Pharmacology, Faculty of Veterinary Medicine, Matrouh University, Egypt.

Abstract | Anti-inflammatory drugs either steroidal or non-steroidal have a dual effect on the animal health. Although they enhance healing process, they seriously affect the clinicopathological parameters. This study aimed to compare the adverse effects of three common anti-inflammatory drugs on some hemato-biochemical parameters and spot the light on the importance of Matrix metalloproteinase-2, -9 (MMP-2, MMP-9) in monitoring the anti-inflammatory action of these drugs. Thirty ewes (1 year, 45 Kg) were randomly divided into 3 equal groups, 1st group (DG) was treated with dexamethasone, 2nd group (DIG) received dipyrone while Meloxicam was given to ewes of the 3rd group (MG). Blood samples were taken on 0, 3, 7, 15 and 21 day post treatment. It was observed that DG showed a significant (P< 0.05) leukocytosis, neutrophilia, eosinophilia, lymphocytopenia at 3rd and 7th day accompanied by hypernatremia at the 3rd day compared to DIG and MG. A significant (P< 0.05) decrease was recorded in MMP-2 and MMP-9 in all treated groups. MMP-2 and MMP-9 returned to their baseline values at 15th and 21st day respectively. The adverse effect of dexamethasone on the leukocytes and serum Na level is more prominent than dipyrone and meloxicam and lasts longer for leukocytes. MMPs may be useful in following up the anti-inflammatory action of dexamethasone, dipyrone and meloxicam.

Keywords | Dexamethasone, Dipyrone, Meloxicam, Clinicopathological parameters, Matrix metalloproteinase-2, -9