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Journal of Animal Health and Production

Research Article
J. Anim. Health Prod. 7(2): 51-57
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Asif ur Rehman1, Arsalan Khan2*, Sarzamin Khan1, Hamza Maris3, Naseer Khan4

1Department of Poultry Science, Faculty of Animal Husbandry and Veterinary Sciences, Agriculture University Peshawar, 25000, Pakistan; 2Livestock Research and Development Station, Paharpur, Dera Ismail Khan-29050-Pakistan; 3Department of Poultry and Animal Sciences, Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan-29050-Pakistan; 4Livestock and Dairy Development Department (Extension), Khyber Pakhtunkhwa Peshawar-25000-Pakistan

Abstract | A study was designed to investigate the effects of quinolones antibiotics on the blood profile, blood glucose level, histomorphological features of pancreas and egg production of laying hens. For this purpose, a total of 48 laying hens were selected and allocated into four groups, each group included three replicates containing four birds in each. Three commonly used quinolones including enrofloxacin, ciprofloxacin and norfloxacin were used for four weeks with one week of adaptation period, while, one group served as negative control. Blood was collected directly from wing vein and serum was analyzed for estimation of blood proteins, glucose level, cholesterol and albumin which showed non-significant (P>0.05) response to quinolones treatment. Highest blood glucose level was measured for control (239.21 ± 5.26), followed by groups treated with enrofloxacin (233.54± 4.19), ciprofloxacin (227.76 ±4.71) and lowest in norfloxacin (225.47 ± 4.85). Highest cholesterol level was measured in groups administered with norfloxacin (164.17± 3.55), followed by control (163.36±1.99), ciprofloxacin (161.53±3.14) and enrofloxacin (160.78± 3.18). The highest level of total protein in blood was recorded in control group (18.51±0.18), followed by enrofloxacin (18.43± 0.27), norfloxacin (18.28± 0.10) and lowest in ciprofloxacin treated group (18.12± 0.36). The highest level of albumin in blood was found in control group (2.82±0.19), followed by enrofloxacin (2.70±0.15), ciprofloxacin (2.61±0.06) and norfloxacin (2.54±0.12). The highest count of WBCs (white blood cells) in blood was recorded for group treated with ciprofloxacin (18.6 ± 10.63), followed by norfloxacin (17.6± 3.63) and control group (17.1± 10.63), while, lowest in enrofloxacin treated group (16.9± 2.53). Total RBCs (red blood cells) and average hemoglobin values showed non-significant (P>0.05) changes in blood profile of laying hens in the treated groups. Hens egg production showed significant (P<0.05) increase in groups treated with different quinolones i.e., 10.95% was in norfloxacin, which was higher than control group followed by group treated with ciprofloxacin (8.63%) and enrofloxacin (6.5%). Histomorphology of pancreas treated with quinolones were noted and findings revealed that quinolones did not affect the histological architecture of the pancreas. It was thus concluded that quinolones have non-significant effect (P>0.05) on the serum biochemistry, blood profile and histomorphology of laying hens.

Keywords | Enrofloxacin, Ciprofloxacin, Norfloxacin, Histomorphology, Laying hens