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Journal of Animal Health and Production

Research Article
J. Anim. Health Prod. 7(2): 43-50
Http://dx.doi.org/10.17582/journal.jahp/2019/7.2.43.50
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Rasha Salah Mohammed1, Gehad Rashad Donia1, Enas Abd El-Aziz Tahoun2, Asmaa Abdallah Darwish1*

1Department of Animal and Poultry Health, Animal and Poultry Production Division, DRC, Cairo, Egypt; 2Pathology Departments, Faculty of Veterinary medicine, University of Sadat City, Egypt.

Abstract | Trypanosoma evansi is an elusive enemy for the immune system, usually resulting in high morbidities and mortalities in different dromedaries. Twenty four albino rats (12 males and 12 females) were used in this study.Samples were collected from four rats before the experiment beginning and from the rest rats weekly until the 35th day, post T. evansi intraperitoneal injection. Results showed a significant increase (P < 0.05) in the concentrations of the pro-inflammatory cytokines, acute phase proteins (APPs), free radicals, immunoglobulins, serum iron, ferritin, transferrin saturation percentage and liver enzymes and this increase was positively correlated with the experiment duration. On contrary, there was a significant decrease (P < 0.05) in the anti-inflammatory cytokine, antioxidants, trace elements, complement-3, complement-4, total iron binding capacity, unsaturated iron binding capacity and transferrin concentrations and this decrease was negatively correlated with the experiment duration. The main lesions in the examined organ sections were hyperemia, necrosis, inflammatory cells infiltration, hyperplasia and fibrosis and these lesions were more prominent in female organs than males. These results demonstrated that the immune response against T. evansi is partially implicated in the disease pathogenesis. Females are more affected by T. evansi infection than males. Moreover, both of the pro-inflammatory cytokines and APPs are sensitive markers for T. evansi infection.

Keywords | Trypanosoma evansi, Rats, Immunity, Histopathological changes, Liver enzymes