Liver, spleen, kidney, heart, lung, stomach, intestine and pancreas from AFB1+AGE treated rat with normal size, shape and colour on Day 28 of the study 

Spleen of AFB1 treated rat showing splenomegaly with rounded border on Day 14 of the study 

Section of liver from control rat on day 14 showing normal appearance of hepatic parenchyma in the portal area H&E X 100 

Section of liver from AFB1 treated rat on day 14 showing swollen, granular and vacuolated appearance of cytoplasm of hepatocytes, severe fatty change, periportal and single cell necrosis, bile duct epithelial hyperplasia, nuclear disintegration and Kupffer cell proliferation H&E X 200 

Section of liver from AFB1+AGE treated rat on day 14 showing swollen and granular appearance of hepatocytes around the portal tract H&E X 200 

Section of liver from AFB1+AGE treated rat on day 28 showing improved architecture of hepatic parenchyma which includes only mild degree of granularity of hepatocytes and sinusoidal congestion and Kupffer cell hyperplasia H&E X 200 

Section of kidney from AFB1 treated rat on day 14 showing swollen and vacuolated appearance of tubular and glomerular epithelium with congestion, haemorrhages, and desquamation of tubular epithelium into the lumen forming hyaline cast H&E X 200 

Section of kidney from AFB1+AGE treated rat on day 14 showing slight swollen tubular and glomerular epithelium with congestion H&E X 200 

Section of spleen from AFB1 treated rat on day 14 showing massive congestion, extensive haemorrhagic areas disrupting the white pulp and occasional histiocytic activity. Also note relative reduction in the white pulp due to massive congestion H&E X 200 

Section of spleen from AFB1+AGE treated rat on day 21 showing secondary lymphoid follicle formation with mild lymphoid necrosis and occasional histiocytic activity H&E X 200